| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-09 |
| タイトル |
|
|
タイトル |
The landscape of 142 Epstein–Barr viral whole genomes in gastric cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Epstein–Barr virus |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gastric cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Epstein–Barr virus-associated gastric cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Viral genome |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Whole-genome sequencing |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
小島, 悠揮
濱田, 太立
Naruse, Azumi
Goto, Kimitoshi
Khine, Htet Thiri
Arai, Haruto
Akutsu, Yuta
Satou, Akira
Nakaguro, Masato
Kato, Seiichi
Kodera, Yasuhiro
Yatabe, Yasushi
Torii, Yuka
Kawada, Jun-Ichi
Murata, Takayuki
Kimura, Hiroshi
瀧口, 修司
稲垣, 宏
片岡, 洋望
奥野, 友介
|
| 抄録(英) |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: A substantial portion of gastric cancer (GC) is linked to Epstein–Barr virus (EBV) infection. The characteristics of this viral genome, such as specific viral strains and large structural variations, influence the progression of diseases like nasopharyngeal carcinoma and hematological malignancy. However, the EBV genomes from GC have not been thoroughly characterized. Methods: Our study involved 849 consecutive GC patients diagnosed at Nagoya City University Hospital, Japan (NCU cohort). We detected EBV from formalin-fixed, paraffin-embedded sections using a novel direct PCR-based rapid detection method. Additionally, we analyzed 142 EBV whole genomes (125 newly sequenced) from GC, comparing them with 205 genomes from other EBV-associated diseases. Results: We identified 32 (3.8%) patients associated with EBVaGC in the NCU cohort. Moreover, the direct PCR identified several GC specimens containing EBV-infected lymphocytes or their follicles. The dominant viral strain in GC was type 1 EBV, prevalent in most parts of the world, and no GC-specific strain was identified. We found no significant associations between single-nucleotide variants in the viral genome and GC. Structural variations of the EBV genome were infrequent in GC (4 cases, 2.1%), contrasting with EBV-associated hematological malignancy, which frequently carries large deletions. Conclusions: This study is the first to uncover the genomic variations of EBV in GC. While EBV is definitively linked to GC, the characteristics of its genomes do not strongly correlate with disease development or progression. Our findings on viral genomes supplement the current understanding of human genomes in EBVaGC. |
|
言語 |
en |
| 書誌情報 |
en : Journal of Gastroenterology
巻 60,
号 1,
p. 55-65,
発行日 2024-11-21
|
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
09441174 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
14355922 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00535-024-02170-3 |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00535-024-02170-3 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
J11-JG-09441174-60-55-oku.pdf (2.2 MB)
